publications

Peer-Viewed Publications

1) Han Y, Junfeng Xu, Jeri Kim, Xifeng Wu, Jian Gu; Methylation of subtelomeric repeat D4Z4 in peripheral blood leukocytes is associated with biochemical recurrence in localized prostate cancer patients, Carcinogenesis. 2017 Aug; 38 (8) : 821–826, doi: 10.1093/carcin/bgx064. PMID: 28854562
 
2) Han Y, Junfeng Xu, Jeri Kim, Xifeng Wu, Jian Gu; LINE-1 methylation in peripheral blood leukocytes and clinical characteristics and prognosis of prostate cancer patients, Oncotarget. 2017 Oct; 8:94020-9402, doi: 10.18632/oncotarget.21511
 
 
3) Han Y, Demorrow S, Invernizzi P, Jing Q, Glaser S, Renzi A, Meng F, Venter J, Bernuzzi F, White M, Francis H, Lleo A, Marzioni M, Onori P, Alvaro D, Torzilli G, Gaudio E, Alpini G.  Melatonin exerts by an autocrine loop antiproliferative effects in cholangiocarcinoma: its synthesis is reduced favoring cholangiocarcinoma growth. Am J Physiol Gastrointest Liver Physiol. 2011 Oct;301(4):G623-33. doi: 10.1152/ajpgi.00118.2011. PMID:  21778461
 

4)  Han Y, Glaser S, Meng F, Francis H, Marzioni M, McDaniel K, Alvaro D, Venter J, Carpino G, Onori P, Gaudio E, Alpini G, Franchitto A.  Recent advances in the morphological and functional heterogeneity of the biliary epithelium. Exp Biol Med (Maywood). 2013 May;238(5):549-65. doi: 10.1177/1535370213489926. Review. PMID:  23856906
 

5) Han Y, Onori P, Meng F, DeMorrow S, Venter J, Francis H, Franchitto A, Ray D, Kennedy L, Greene JF, Renzi A, Mancinelli R, Gaudio E, Glaser S, Alpini G. Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 11. doi: 10.1039/c4cc04835k. PMID: 25214401
 

6) Han Y*, Francis H*, McDaniel K*, Liu X, Kennedy L, Yang F, McCarra J, Zhou T, Glaser S, Venter J, Huang L, Levine P, Lai JM, Liu CG, Alpini G, Meng F. Regulation of the extrinsic apoptotic pathway by microRNA-21 in alcoholic liver injury. J Biol Chem. 2014 Oct 3. doi: 10.1074/jbc.M114.602383. PMID: 25118289  (Equal contribution first-author)
7) Han Y, Meng F, Venter J, Wu N, Wan Y, Standeford H, Francis H, Meininger C, Greene J Jr, Trzeciakowski JP, Ehrlich L, Glaser S, Alpini G. miR-34a-dependent overexpression of Per1 decreases cholangiocarcinoma growth. J Hepatol. 2016 Jun;64(6):1295-304. doi: 10.1016/j.jhep.2016.02.024. Epub 2016 Feb 24. PMID: 26923637

Book Chapters

 
1) DeMorrow S, Francis H, Marzioni M, Leyva-ILLades D, Han Y, Alpini G, “Cholangiocarcinoma.” in Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms; Ed: McManus L and Mitchell R. ISBN: 978-0-12-386457-4, Elseiver, Inc., Waltham, MA

2) Han Y*, Ray D*, Maroni L,… Glaser S et al, “ Liver Regeneration: The Biliary Perspective” In Liver Regeneration: Basic Mechanisms, Relevant Models and Clinical Applications; Ed: Apte U; ISBN: 978-0-12-420128-6, Elseiver, Inc., Waltham, MA

Co-authored Publication

1) Alpini G, Franchitto A, Demorrow S, Onori P, Gaudio E, Wise C, Francis H, Venter J, Kopriva S, Mancinelli R, Carpino G, Stagnitti F, Ueno Y, Han Y, Meng F, Glaser S. Activation of alpha(1) -adrenergic receptors stimulate the growth of small mouse cholangiocytes via calcium-dependent activation of nuclear factor of activated T cells 2 and specificity protein 1.   Hepatology. 2011 Feb;53(2):628-39. doi: 10.1002/hep.24041. PMID: 21274883
 
2) Renzi A, Glaser S, Demorrow S, Mancinelli R, Meng F, Franchitto A, Venter J, White M, Francis H, Han Y, Alvaro D, Gaudio E, Carpino G, Onori P, Alpini G.  Melatonin inhibits cholangiocyte hyperplasia in cholestatic rats by interaction with MT1 but not MT2 melatonin receptors. Am J Physiol Gastrointest Liver Physiol. 2011 Oct;301(4):G634-43. doi: 10.1152/ajpgi.00206.2011.  PMID:  21757639
 
3) Meng F, Han Y, Staloch D, Francis T, Stokes A, Francis H.  The H4HR agonist, clobenpropit, suppresses human cholangiocarcinoma progression by disruption of EMT and tumor metastasis. Hepatology. 2011 Nov;54(5):1718-28. doi: 10.1002/hep.24573. PMID:  21793031
 
4) Alpini G, Glaser SS, Zhang JP, Francis H, Han Y, Gong J, Stokes A, Francis T, Hughart N, Hubble L, Zhuang SM, Meng F.  Regulation of placenta growth factor by microRNA-125b in hepatocellular cancer. J Hepatol. 2011 Dec;55(6):1339-45. doi: 10.1016/j.jhep.2011.04.015. PMID:  21703189
 
5)  Meng F, Francis H, Glaser S, Han Y, Demorrow S, Stokes A, Staloch D, Venter J, White M, Ueno Y, Reid LM, Alpini G.  Role of stem cell factor and granulocyte-colony stimulating factor in remodeling during liver regeneration. Hepatology. 2012 Jan;55(1):209-21. doi: 10.1002/hep.24673. PMID:  21932404
 
6) Meng F, Glaser SS, Francis H, Yang F, Han Y, Stokes A, Staloch D, McCarra J, Liu J, Venter J, Zhao H, Liu X, Francis T, Swendsen S, Liu CG, Tsukamoto H, Alpini G. Functional analysis of microRNAs in human hepatocellular cancer stem cells. J Cell Mol Med. 2012 Jan;16(1):160-73. doi: 10.1111/j.1582-4934.2011.01282.x. PMID:  22352471
 
7)  Johnson C, Han Y, Hughart N, McCarra J, Alpini G, Meng F.  Interleukin-6 and its receptor, key players in hepatobiliary inflammation and cancer. Transl Gastrointest Cancer.  2012 Apr 1;1(1):58-70. doi:  10.3978/j.issn.2224-4778.2011.11.02. PMID: 22724089
 
8) Meng F, Glaser SS, Francis H, Yang F, Han Y, Stokes A, Staloch D, McCarra J, Liu J, Venter J, Zhao H, Liu X, Francis T, Swendsen S, Liu CG, Tsukamoto H, Alpini G.  Epigenetic regulation of miR-34a expression in alcoholic liver injury. Am J Pathol. 2012 Sep;181(3):804-17. doi: 10.1016/j.ajpath.2012.06.010. Epub 2012 Jul 25.  PMID:  22841474
 
9) Renzi A, Demorrow S, Onori P, Carpino G, Mancinelli R, Meng F, Venter J, White M, Franchitto A, Francis H, Han Y, Ueno Y, Dusio G, Jensen KJ, Greene JJ, Glaser S, Gaudio E, Alpini G.  Modulation of the biliary expression of arylalkylamine N-acetyltransferase alters the autocrine proliferative responses of cholangiocytes. Hepatology. 2013 Mar;57(3):1130-41. doi: 10.1002/hep.26105. Epub 2013 Feb 7. PMID: 23080076
 
10) Mancinelli R, Franchitto A, Glaser S, Meng F, Onori P, Demorrow S, Francis H, Venter J, Carpino G, Baker K, Han Y, Ueno Y, Gaudio E, Alpini G.  GABA induces the differentiation of small into large cholangiocytes by activation of Ca(2+) /CaMK I-dependent adenylyl cyclase 8.  Hepatology. 2013 Jul;58(1):251-63. doi: 10.1002/hep.26308. Epub 2013 May 14. PMID: 23389926
 
11) McDaniel K, Herrera L, Zhou T, Francis H, Han Y, Levine P, Lin E, Glaser S, Alpini G, Meng F.  The functional role of microRNAs in alcoholic liver injury. J Cell Mol Med. 2014 Jan 8. doi: 10.1111/jcmm.12223. [Epub ahead of print]  PMID: 24400890

12) Glaser S, Han Y, Francis H, Alpini G. Melatonin regulation of biliary functions. Hepatobiliary Surg Nutr. 2014;3:35-43. doi: 10.3978/j.issn.2304-3881.2013.10.04. Review. PMID: 24696836
 
13)  Meng F, Onori P, Hargrove L, Han Y, Kennedy L, Graf A, Hodges K, Ueno Y, Francis T, Gaudio E, Francis HL.  Regulation of the Histamine/VEGF Axis by miRNA-125b during Cholestatic Liver Injury in Mice. Am J Pathol. 2013 Dec 30. pii: S0002-9440(13)00786-4. doi: 10.1016/j.ajpath.2013.11.008. [Epub ahead of print] PMID: 24384130
 
14) Meng F, Demorrow S, Venter J, Frampton G, Han Y, Francis H, Standeford H, Avila S, McDaniel K, McMillin M, Afroze S, Guerrier M, Quezada M, Ray D, Kennedy L, Hargrove L, Glaser S, Alpini G. Overexpression of membrane metalloendopeptidase inhibits substance P-stimulation of cholangiocarcinoma growth. Am J Physiol Gastrointest Liver Physiol. 2014 Mar 6. doi: 10.1152/ajpgi.00018.2014 [Epub ahead of print] PMID: 24603459
 
15)  Glaser S, Meng F, Han Y, Onori P, Chow BK, Francis H, Venter J, McDaniel K, Marzioni M, Invernizzi P, Ueno Y, Lai JM, Huang L, Standeford H, Alvaro D, Gaudio E, Franchitto A, Alpini G. Secretin Stimulates Biliary Cell Proliferation by Regulating Expression of MicroRNA 125b and MicroRNA let7a in Mice. Gastroenterology. 2014 Feb 25. pii: S0016-5085(14)00241-8. doi: 10.1053/j.gastro.2014.02.030. [Epub ahead of print] PMID: 24583060
 
16) Graf A, Meng F, Hargrove L, Kennedy L, Han Y, Francis T, Hodges K, Ueno Y, Nguyen Q, Greene JF, Francis H. Knockout of histidine decarboxylase (HDC) decreases BDL-induced biliary hyperplasia via downregulation of the HDC/VEGF axis through PKA-ERK1/2 signaling. Am J Physiol Gastrointest Liver Physiol. 2014 Aug 28. pii: ajpgi.00288.2014. PMID:25169977
 
17)  Huang L, Chen W, Liang P, Hu W, Zhang K, Shen S, Chen J, Zhang Z, Chen B, Han Y, Meng F, DeMorrow S, Yin X, Lai J, Liang L. Serum CYFRA 21-1 in Biliary Tract Cancers: A Reliable Biomarker for Gallbladder Carcinoma and Intrahepatic Cholangiocarcinoma. Dig Dis Sci. 2014 Dec 9. [Epub ahead of print]. doi: 10.1007/s10620-014-3472-0. PMID: 25487191
 
18) Ray D, Han Y, Franchitto A, DeMorrow S, Meng F, Venter J, McMillin M, Kennedy L, Francis H, Onori P, Mancinelli R, Gaudio E, Alpini G, Glaser SS. Gonadotropin-releasing hormone stimulates biliary proliferation by paracrine/autocrine mechanisms. Am J Pathol. 2015 Apr;185(4):1061-72. doi: 10.1016/j.ajpath.2014.12.004. PMID: 25794706
 
19)  Meng L, Quezada M, Levine P, Han Y, McDaniel K, Zhou T, Lin E, Glaser S, Meng F, Francis H, Alpini G. Functional Role of Cellular Senescence in Biliary Injury. Am J Pathol. 2015 Mar;185(3):602-609. doi: 10.1016/j.ajpath.2014.10.027. Epub 2015 Jan 22. PMID: 25619959
 
20) Wan Y, Garner J, Wu N, Phillip L, Han Y, McDaniel K, Annable T, Zhou T, Francis H, Glaser S, Huang Q, Alpini G, Meng F. Role of stem cells during diabetic liver injury.
J Cell Mol Med. 2016 Feb;20(2):195-203. doi: 10.1111/jcmm.12723. Epub 2015 Dec 9. Review. PMID: 26645107

21)  Johnson C, Huynh V, Hargrove L, Kennedy L, Graf-Eaton A, Owens J, Trzeciakowski JP, Hodges K, DeMorrow S, Han Y, Wong L, Alpini G, Francis H. Inhibition of Mast Cell-Derived Histamine Decreases Human Cholangiocarcinoma Growth and Differentiation via c-Kit/Stem Cell Factor-Dependent Signaling. Am J Pathol. 2016 Jan;186(1):123-33. doi: 10.1016/j.ajpath.2015.09.016. Epub 2015 Nov 18. PMID: 26597881
 

22)  Wu N, Meng F, Zhou T, Han Y, Kennedy L, Venter J, Francis H, DeMorrow S, Onori P, Invernizzi P, Bernuzzi F, Mancinelli R, Gaudio E, Franchitto A, Glaser S, Alpini G. Prolonged darkness reduces liver fibrosis in a mouse model of primary sclerosing cholangitis by miR-200b down-regulation. FASEB J. 2017 Jun 20. pii: fj.201700097R. doi: 10.1096/fj.201700097R. [Epub ahead of print] PMID:28634212